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Unfortunately, at present, no more effective measures can completely alleviate or reverse tissue fibrosis, so symptomatic treatments for fibrosis-related symptoms are commonly adopted, like non-steroidal anti-inflammatory drugs (NSAIDs) for muscular pain, injection of botulinum toxin for dystonia, and oxygen therapy or mechanical ventilation for respiratory failure

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Because they act through non-overlapping mechanisms, some protocols examine them in combination or parallel though combination research should have a clear mechanistic rationale

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These mitokines interact with several neurotrophic and growth factors, notably brain-derived neurotrophic factor (BDNF) and insulin-like growth factor 1 (IGF-1) [14]

Bedford MT, Frankel A, Yaffe MB, Clarke S, Leder P, Richard S (2000) Arginine methylation inhibits the binding of proline-rich ligands to Src homology 3, but not WW, domains